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KMID : 0811720150190060543
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Korean Journal of Physiology & Pharmacology
2015 Volume.19 No. 6 p.543 ~ p.547
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Combined Skin Moisturization of Liposomal Serine Incorporated in Hydrogels Prepared with Carbopol ETD 2020, Rhesperse RM 100 and Hyaluronic Acid
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Kim Hyeong-Min
Ro Ji-Eun
Sonia Barua
Hwang Deuk-Sun
Na Seon-Jeong
Lee Ho-Sung
Jeong Ji-Hoon
Woo Seul-ki
Kim Hye-won
Hong Bo-mi
Yun Gyi-Ae
Kim Joong-Hark
Yoon Young-Ho
Park Myung-Gyu
Kim Ji-a
Sohn Uy-Dong
Lee Jae-Hwi
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Abstract
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We investigated the combined moisturizing effect of liposomal serine and a cosmeceutical base selected in this study. Serine is a major amino acid consisting of natural moisturizing factors and keratin, and the hydroxyl group of serine can actively interact with water molecules. Therefore, we hypothesized that serine efficiently delivered to the stratum corneum (SC) of the skin would enhance the moisturizing capability of the skin. We prepared four different cosmeceutical bases (hydrogel, oil-in-water (O/W) essence, O/W cream, and water-in-oil (W/O) cream); their moisturizing abilities were then assessed using a Corneometerⓡ. The hydrogel was selected as the optimum base for skin moisturization based on the area under the moisture content change-time curves (AUMCC) values used as a parameter for the water hold capacity of the skin. Liposomal serine prepared by a reverse-phase evaporation method was then incorporated in the hydrogel. The liposomal serine-incorporated hydrogel (serine level=1%) showed an approximately 1.62∼1.77 times greater moisturizing effect on the skin than those of hydrogel, hydrogel with serine (1%), and hydrogel with blank liposome. However, the AUMCC values were not dependent on the level of serine in liposomal serine-loaded hydrogels. Together, the delivery of serine to the SC of the skin is a promising strategy for moisturizing the skin. This study is expected to be an important step in developing highly effective moisturizing cosmeceutical products.
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KEYWORD
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Corneometer, Hydrogel, Liposome, Serine, Skin moisturization
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